POTENTIATING VASCULAR-TARGETED PHOTODYNAMIC THERAPY THROUGH CSF-1R MODULATION OF MYELOID CELLS IN A PRECLINICAL MODEL OF PROSTATE CANCER

Potentiating vascular-targeted photodynamic therapy through CSF-1R modulation of myeloid cells in a preclinical model of prostate cancer

Vascular-targeted photodynamic therapy (VTP) induces rapid destruction of targeted tissues and is a promising therapy for prostate cancer.However, the resulting immune response, which may play an important role in either potentiating or blunting the effects of VTP, is still incompletely understood.Myeloid cells such as read more myeloid-derived sup

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Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway.

The maintenance of cellular proteins in a biologically active and structurally stable state is a vital endeavor involving multiple cellular pathways.One such pathway is the ubiquitin-proteasome system that represents a major route for protein degradation, and reductions in this pathway usually have adverse effects on the health of cells and tissues

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